Anybody on Targin?its an oxycodone/naloxone cr medication.most research just says its better for constipation,but i have read articles stating that ultra low doses of an opioid antagonist, naloxone,can help improve analgesia and reduce tolerance as well....
Mrs Shingles Endone is oxycodone hydrocholride, Targin is oxycodone hydrocholride that has the added ingredient naloxone hydrochloride dihydrate to help with constipation, so watch you you don't double up on doses.
Is targin just OxyContin with the naloxone added to help with the constipation?or is it an immediate release medication,or available as both?the info on the net is a bit hazy.but I would really be interested to know if the targin seems more effective for pain relief than an OxyContin tablet,as my doctor has been uncomfortable with continually increasing my dosage every three months,and from my own research have wondered if the naloxone might stabilise my tolerance somewhat due to its antagonistic properties.
not 100% sure here but i think you will find the main marketting target of the oxycodene and naloxone combinations is to help with the constipation side of things, particualarly in palliative care patients- but there has been some theories about the use of opioid antagognists (naloxone) in combination with some opiods was actually more effective- i don't know much about ti but i o remember the fisrt time i read any mention of naloxone to assist with chronic pain control, would have been probably at least 10 yrs ago- i remember because at the time as a nurse my knowledge of naloxone was as the drug narcan, used to reverse the effectis of overdoses of opioids- in more recent times i have read how the combination works to blok the narcotic effcts t some extent at the bowel loevel so that the bowel does nt slow and lead to the typical constipation- but even if that is the major reason the drug combination is marketed, does not mean its the only use. look at lyrica, it was an anticonvulsant first!
if you havetrouble finding information relating to pain control and the combination of oxycodone and naloxone, try searching just ultralow dose naloxone instead, i think you will find more
Thanks kebsa,hopefully further research is put into this combination,I really think that finding the right combination of agonist/antagonist will be essential in future pain management planning and maintenance.
glad to hear its helping and that things are improving!
as for my comments before, i have been trying to remember a bit more about it but it was a long time ago (at least a decade) back then i used to be a memeber of an america pain support forum as i had not found an australian one and there were a few people on the board that talked about "low dose naltrexone" opioid combibations- naltrexone is not exactly the same as naloxone, its a milder version but its still an opioid antagnosist - it stuck in my mind as it seemed bizarre t use an opioid antagnosit in combination with a narcotic but i do remember others on the board reporting good results. As for Targin, until this thread i had only heard of it as a pain killer used in palliative care to help avoid the really troublesome issues of constipation. From the little i have read it sounds like they are getting smarter in being able to target nerve receptors a bit more selelctively. in recent yrs there has been more an more done with the time relelased opioids but i think they have had their fun with that and are now looking for more novel ways particularly anything that will mean these drugs are not diverted into black market use so easily- thats become a huge problem and ultimately makes it hard for pain management specialist and people like us